finasteride
Propecia · Proscar
1 INDICATIONS & USAGE Finasteride tablets USP are indicated for the treatment of male pattern hair loss (androgenetic alopecia) in MEN ONLY. Efficacy in bitemporal recession has not been established. Finasteride tablets USP are not indicated for use in women. • Finasteride tablets USP are 5α-reductase inhibitors indicated for the treatment of male pattern hair loss (androgenetic alopecia) in MEN ONLY ( 1 ). • Finasteride tablets USP are not indicated for use in women ( 1 , 4 , 5.1 ).
Mechanism. 12.1 Mechanism of Action Finasteride is a competitive and specific inhibitor of Type II 5α-reductase, an intracellular enzyme that converts the androgen testosterone into DHT. Two distinct isozymes are found in mice, rats, monkeys, and humans: Type I and II. Each of these isozymes is differentially expressed in tissues and developmental stages. In humans, Type I 5α-reductase is predominant in the sebaceous glands of most regions of skin, including scalp, and liver. Type I 5α-reductase is responsible for approximately one-third of circulating DHT. The Type II 5α-reductase isozyme is primarily found in prostate, seminal vesicles, epididymides, and hair follicles as well as liver, and is responsible for two-thirds of circulating DHT. In humans, the mechanism of action of finasteride is based on its preferential inhibition of the Type II isozyme. Using native tissues (scalp and prostate), in vitro binding studies examining the potential of finasteride to inhibit either isozyme revealed a 100-fold selectivity for the human Type II 5α-reductase over Type I isozyme (IC 50 =500 and 4.2 nM for Type I and II, respectively). For both isozymes, the inhibition by finasteride is accompanied by reduction of the inhibitor to dihydrofinasteride and adduct formation with NADP+. The turnover for the enzyme complex is slow (t 1/2 approximately 30 days for the Type II enzyme complex and 14 days for the Type I complex). Inhibition of Type II 5α-reductase blocks the peripheral conversion of testost
What stands out in the reports.
ROR = reporting odds ratio (log-schaal). Een waarde boven 1 betekent dat het symptoom vaker wordt gemeld voor dit product dan voor alle andere producten samen. Dit meet hoeveel het opvalt in meldingen — geen causaliteit, geen risico.
Le finastéride inhibe la 5-alpha-réductase, réduisant la conversion de la testostérone en dihydrotestostérone (DHT). Les effets indésirables sexuels (dysfonction sexuelle, perte de libido, dysfonction érectile, diminution de la libido) sont fréquemment notifiés et disproportionnellement signalés (ROR très élevés). Ceci est logique, la DHT jouant un rôle clé dans la fonction sexuelle masculine. Les troubles psychiatriques (idées suicidaires, dépression, anxiété) sont aussi disproportionnellement notifiés. Le lien avec le mécanisme d'action est moins évident mais fait l'objet de recherches. **« Fréquemment notifié » n'est pas synonyme de « fréquemment causé ».** Ceci ne remplace pas un avis médical.
Dit vervangt geen medisch advies.
No signals currently mapped to the label.
Report volume per quarter.
No recalls on record.